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However, no matter what way you choose to cleanse your liver, it is a must that you cleanse your colon and kidneys before you do your liver. The reason for this is that, during detoxification of liver, the toxins from liver are released into the colon and kidneys. These toxins need to be removed from the body as early as possible, if not on an immediate basis. If colon and kidneys do not function at their best during this time, the toxins will stay in the body for a longer time. Hence, it is a must that these organs should be detoxified well in advance, so that they can efficiently handle the added responsibility.